The biosynthesis of hemoglobin from iron, protoporphyrin and globin.
نویسندگان
چکیده
منابع مشابه
An intracellular protein intermediate for hemoglobin formation.
Iron and amino acids enter young red cells and are incorporated into hemoglobin, but the pathway of iron after entering the erythroblast is not understood nor is it clear in what sequence iron, protoporphyrin, and globin join to form a complete hemoglobin molecule. Several lines of evidence have suggested the presence of an intracellular, nonheme iron protein that may be an intermediate in the ...
متن کاملThe utilization of glycine in the biosynthesis of hemoglobin.
Isotopic studies have demonstrated that glycine is used in the biosynthesis of hemoglobin. Glycine has been tagged in one of three ways: (a) with N’” in the amino group (l-3), (b) with Cl4 in the a-methylene carbon position (4), and (c) with Cl4 in the carboxyl group (5). When any of these three forms of glycine is fed to animals, the isotope is incorporated into hemoglobin, but interesting dif...
متن کاملCircular dichroism of hemoglobin in relation to the structure surrounding the heme.
Circular dichroism (CD) of various kinds of hemoglobins and the protoporphyrin-globin complex has been measured over the range of 200 to 660 nm. All mammalian hemoglobins so far tested show CD spectra identical with those of human hemoglobin. Although the absorption spectra of lamprey hemoglobin and toad embryonic hemoglobin are similar to those of human hemoglobin, these hemoglobins show vario...
متن کاملBiology of Heme in Mammalian Erythroid Cells and Related Disorders
Heme is a prosthetic group comprising ferrous iron (Fe(2+)) and protoporphyrin IX and is an essential cofactor in various biological processes such as oxygen transport (hemoglobin) and storage (myoglobin) and electron transfer (respiratory cytochromes) in addition to its role as a structural component of hemoproteins. Heme biosynthesis is induced during erythroid differentiation and is coordina...
متن کاملSPECTROPHOTOMETRIC MICROMETHOD FOR THE QUANTITATIVE DETERMINATION OF THE FREE ERYTHROCYTE PROTOPORPHYRIN” BY MOISl% GRINSTEINt
Interesthas developed recently (l-3) in the significance of the free protoporphyrin which van den Bergh and Hyman (4) reported in 1928 as being present in human erythrocytes. This “erythrocyte protoporphyrin” (EP) is identical with the protoporphyrin which, in combination with iron and globin, forms hemoglobin (1, 5). An increase in the quantity of free EP has been observed in immature erythroc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 40 شماره
صفحات -
تاریخ انتشار 1961